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. 2018 Mar 20;72(5):657–664. doi: 10.1038/s41430-018-0138-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Concept of ‘collateral fattening’. A deficit in FFM results not only in a lower energy expenditure (EE) and hence lower energy needs for weight maintenance, but also in the activation a feedback loop that drives energy intake (E_IN) in an attempt to restore FFM through the lean-to-fat partitioning characteristic (Pc) of the individual; reproduced from Dulloo et al. [7]