Fig. 5.

Conceptual overview of the factors contributing to hyperphagia, which could operate at different rates as well as with different magnitude. Lean (protein) tissue synthesis and retention may lag behind fat tissue synthesis and storage, because of the more complex and differently regulated metabolism in the former, as well as its limited deposition, in particular in non-stimulated muscles, that is, without associated exercise. Despite a constant intrinsic partitioning characteristic (Pc), more body fat can be deposited in situation of high and rapid degree of hyperphagia leading to faster catch-up fat relative to lean tissue, temporal desynchronization in reaching complete fat vs. lean mass recovery, and collateral fattening resulting in fat overshoot and altered body composition with a higher degree of adiposity