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. 2018 May 10;9(5):540. doi: 10.1038/s41419-018-0597-7

Fig. 4. cZRANB1 knockdown affects glial cell activation in vivo.

Fig. 4

a, b The rat retinas were injected with 5 μl scramble (Scr) shRNA, cZRANB1 shRNA-1, or PBS buffer for 7 days, and then injected with the microbead for 8 weeks. The retinas only injected with PBS buffer were taken as the control group. Retinal slices were stained with PCNA and GS antibody to detect glial cell proliferation (a; *P < 0.05 vs. buffer group; n = 5). Retinal slices were stained with Nestin (b; *P < 0.05 vs. buffer group; n = 5) to investigate the effect of cZRANB1 knockdown on the reactivation of stem and progenitor properties of glial cells. Scale bar, 100 µm. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer