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. 2018 May 10;8:7449. doi: 10.1038/s41598-018-25929-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of XSECC on glucose metabolism in BCCAO rats. ¹⁸F-FDG PET images of the (a) coronal and (b) axial planes. PET images are co-registered with the CT of the same animal to localize anatomically the PET signal. (c) Quantitative analysis of SUV of ¹⁸FDG in the hippocampus. ^##P < 0.01 vs. sham group; *P < 0.05, **P < 0.01 vs. model group (one-way ANOVA followed by LSD’s post hoc test, n = 6 per group). (d) Person correlational analysis of the hippocampal SUV and Morris water maze parameters of the probe test. A positive correlation was found between the hippocampal SUV and path (Pearson R² = 0.46, P = 0.0002), time spent in the target quadrant (Pearson R² = 0.38, P = 0.0013) of the probe test (Pearson correlational analysis).