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. 2018 May 10;8:7490. doi: 10.1038/s41598-018-25377-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADAS-Cog11 Slopes in subjects with high or low probability of MCI due to AD. X-axis depicts maximum duration of follow up. Y-axis depicts ADAS-Cog11 scores. MCI subjects have been grouped using CSF t-tau/Aβ42 ratio as having “high” or “low” probability of MCI due to AD. Slopes and confidence intervals are derived from a simple quadratic model (polynomial regression) by sex over time without any other covariates. Data comprises pooled MCI subjects from ADNI-1 and ADNI-2. Female subjects with high probability of MCI due to AD showed greater decline than the other groups.