Table 1.
Baseline Demographic and Clinical Characteristics by Sex of Subjects.
| ADNI MCI | All | Female | Male | p-value |
|---|---|---|---|---|
| No. subjects | 559 | 216 | 343 | |
| Age (years) | 74.0/7.5 | 72.8/7.6 | 74.8/7.4 | 0.002 |
| Education (years) | 15.9/2.9 | 15.4/2.8 | 16.2/3.0 | 0.004 |
| MMSE | 27.2/1.8 | 27.1/1.8 | 27.2/1.8 | 0.492 |
| ADAS-Cog11 | 11.5/4.6 | 11.2/4.8 | 11.7/4.4 | 0.158 |
| APOE ε4 carriers (%) | 54 | 58 | 52 | 0.196 |
| MCI due to AD – high likelihood (%) | 69.5 | 73.0 | 67.3 | |
| Follow-up Duration (months) | 43.8/29.6* | 42.4/27.3* | 44.8/30.9* | 0.351 |
| Total hippocampal volume (mm3) | 5901.1/ 1079.3 (n = 443) | 5678.9/1073.5 (n = 168) | 6036.9/ 1062.0 (n = 275) | <0.001 |
| “MCI due to AD – high likelihood” | All | Female | Male | p-value |
| No. subjects | 244 | 100 | 144 | |
| Age (years) | 73.6/7.3 | 71.3/7.2 | 75.1/6.9 | <0.001 |
| Education (years) | 16.1/2.8 | 15.5/2.8 | 16.5/2.8 | 0.006 |
| MMSE | 27.0/1.8 | 26.9/1.8 | 27.0/1.9 | 0.663 |
| ADAS-Cog11 | 12.6/4.9 | 12.3/4.9 | 12.8/4.8 | 0.511 |
| APOE ε4 carrier (%) | 70 | 76 | 65 | 0.098 |
| Follow-up Duration (months) | 40.4/24.8 | 38.7/22.9 | 39.7/27.0 | 0.770 |
| Total hippocampal volume (mm3) | 5773.4/1006.0 (n = 184) | 5622.2/1011.4 (n = 77) | 5882.2/992.6 (n = 107) | 0.084 |
ANOVA (Analysis of variance) assessed differences in age, education year, follow-up duration and ANCOVA (Analysis of covariance) assessed sex-differences in baseline MMSE and ADAS-Cog11 scores adjusting for age, years of education. Data are expressed as mean/standard deviation, as appropriate. Bold p-values are statistically significant. Abbreviations: AD (Alzheimer’s disease), MCI (mild cognitive impairment), ADAS-Cog11 (Alzheimer’s disease assessment scale- cognitive subscale), MMSE (mini- mental state examination), and APOE ε4 (apolipoprotein ε4 allele). Follow-up duration is calculated based on ADAS-Cog 11 measurement. CSF t-tau/Aβ42 ratio cut-offs were used to classify subjects as having “high” likelihood of meeting criteria for “MCI due to AD”. See text for details.