Skip to main content
. 2018 May 10;8:7490. doi: 10.1038/s41598-018-25377-w

Table 3.

Effect of Sex and CSF Aβ42 on longitudinal change in ADAS-Cog11 of MCI subjects.

Term Coefficient Standard error t-value p-value
Intercept 3.877795 0.06891898 56.26600 <0.001
Sex effect 0.223058 0.10668516 2.09081 0.037
Aβ42 effect −0.007031 0.00100517 −6.99508 <0.001
Baseline rate 0.023720 0.00184203 12.87688 <0.001
Baseline curvature 0.000177 0.00002078 8.52360 <0.001
Age effect 0.002999 0.00680578 0.44068 0.660
Education effect 0.000530 0.01816607 0.02918 0.977
Baseline cognition effect 0.139866 0.01143890 12.22720 <0.001
Female effect on slope 0.006420 0.00290663 2.20866 0.027
Female effect on curvature −0.000006 0.00003607 −0.15359 0.878
Baseline Aβ42 effect on slope −0.000216 0.00002632 −8.21396 <0.001
Baseline Aβ42 effect on curvature −0.000001 0.00000028 −3.52631 <0.001
Education effect on slope 0.000301 0.00048418 0.62259 0.534
Age effect on slope −0.000006 0.00018281 −0.03192 0.975
Baseline cognition effect on slope 0.000378 0.00030937 1.22315 0.221

Baseline cognition indicates ADAS-Cog 11. Bold p-values are statistically significant. Abbreviations: MCI (mild cognitive impairment), ADAS-Cog11 (Alzheimer’s disease assessment scale- cognitive subscale), and Aβ42 (amyloid-beta1–42). In this model, the follow-up time (month) was centered with the median follow-up time (36 months) and covariates were centered i.e. a 75 years old with 16 years of education, ADAS-Cog11 of 11, and Aβ42 of 147. Table depicts that the effect of sex on ADAS-Cog11 slope was significant with females declining faster than males. Baseline Aβ42 also had a significant effect on both slope and curvature. Age and education did not have significant effects on slope. The intercept is a term to get the correct estimate of the outcome when time = 0. The baseline rate is the reference population rate of change in the outcome starting at time zero, and the baseline curvature is the “acceleration” of that rate of change at time zero. The upper half of the table shows the effect of specific variables on ADAS-Cog11 and the bottom half shows their effects on ADAS-Cog11 slope and curvature.