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. 2018 May 10;4:59. doi: 10.1038/s41420-018-0055-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Upper panel: TEM micrographs of hpOBs. a Normo-gravity control mature hpOBs micrograph taken at 110 h time point. Ultrastructural image show osteoblast cell with intracellular granules of HA crystals (highlighted by arrows). b Mature osteoblasts exposed to 110 h Sμg. Image represent 90% of cells, which show large cells without both profuse endoplasmic reticulum and intracellular granules of HA crystals. c Representative TEM micrograph of 4% of cell after 110 h Sμg. Images display a “mesenchymal-like” cell induced from 110 h-Sμg treatment. Lower panel: Downregulation of pro-osteogenic proteins. The tables reports differential spectral-counts between normo-gravity and Sμg conditions. Protein content was estimated as normalized EmPAI values as percentage according to Shinoda et al. The table shows proteins differentially regulated in abundance with statistical significance. *p < 0.05; **p < 0.01; ***p < 0.001, and unique proteins in normo-gravity (UN) and microgravity (UM)