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. 2018 May 10;4:59. doi: 10.1038/s41420-018-0055-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Upper panel: Wound assay on hpOB cells normo-gravity vs. Sμg. a Scratched cell monolayer recorded at t0. b The wound after 24 h under normo-gravity. c The wound after 24 h Sμg exposition. Dashed lines highlight the place where the scratch occurred (microscopic magnification 4×). Lower panel: Cell migrating front: ZOOM of hpOBs at 18 h after the wound: normo-gravity vs. Sμg. d, e Micrograph of hpOBs close to leading edge under normo-gravity conditions from upright and inverted microscope, respectively. Images display no/rare cellular structures compatible with cell protrusions (filopodia or lamellipodia). f, g Images show osteoblasts next to leading edge after 18 h microgravity incubation from upright and inverted microscope, respectively. Arrows indicate the presence of several lamellipodia or filopodia-like protrusions. Toluidine blue staining in pictures from inverted microscope