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. 2018 May 10;4:59. doi: 10.1038/s41420-018-0055-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Microgravity uncovers a developmental state transition on human osteoblasts. Upon simulated microgravity exposition human primary osteoblasts assume spindle-shape morphology reverting the mature phenotype and their specialized functions. A mature osteoblast cell loses levels of bone crystal deposit, osteogenic markers, and adhesive proteins, enhancing prior developmental state features (glycolysis, pre-osteoblast state marker, and cell protrusions), which in turn allows it to acquire motility properties.