Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ODN inhibition of the HIV-1 IN LEDGF/p75-independent activity.
| Compound | aIC50 IN LEDGF-independent integration (µM) |
|---|---|
| INTB-H2 | 0.145 ± 0.005 |
| INTB-H5 | 0.150 ± 0.030 |
| INTB-H9 | 0.178 ± 0.002 |
| INTB-H13 | 0.225 ± 0.005 |
| INTB-H17 | 0.225 ± 0.045 |
| INTB-nat | 0.270 ± 0.020 |
| Raltegravir | 0.058 ± 0.010 |
aCompound concentration required to inhibit the HIV-1 IN catalytic activities, in the absence of LEDGF, by 50%. Raltegravir has been used as a reference. See main text for details.
