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. 2018 May 10;9:1857. doi: 10.1038/s41467-018-04208-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Selected associations between mutational process exposures and driver mutations within cancer types. Q-values shown are for Mann–Whitney U-test. a KRAS G12C and signature 4 in lung adenocarcinoma. b PIK3CA E545K and signature 2 in breast cancer c FBXW7 R465C and Signature 15 in stomach cancer d KRAS G12D and signature 26 in uterine carcinoma e PTEN R130Q and signature 10 in uterine carcinoma f APC R213X and signature 1 in colorectal cancer. Centre line shows median; box shows inter-quartile range; upper whisker shows the upper quartile plus one and a half times the inter-quartile range, or the maximum data point (if lower); lower whisker shows the lower quartile minus one a half times the inter-quartile range, or the minimum data point (if higher)