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. 2018 May 10;9:1857. doi: 10.1038/s41467-018-04208-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Evidence for differential selection between mutations in KRAS, BRAF and NRAS. Bar plots show modelled relative risk of KRAS, BRAF, and NRAS mutations (compared with a reference mutation). a Modelled relative risk of KRAS, BRAF and NRAS, mutations compared to KRAS G12R in pancreatic cancer. b As above, with comparison to KRAS G12V mutations in uterine carcinoma. c As above, with comparison to BRAF V600E mutations in thyroid cancer. d As above, with comparison to BRAF V600E mutations in melanoma. e As above, with comparison to BRAF V600E in colorectum. f As above, with comparison to KRAS G12C in lung adenocarcinoma. Confidence intervals obtained by bootstrapping across 100 iterations. Error bars represent 95% confidence intervals obtained by bootstrapping across 100 iterations. N indicates total number of samples used for the analysis within each cancer type