Fig. 3.

Interplay between genetics, DNA methylation and COPD status at IREB2 gene. a The frequency of T and C alleles of rs12914385:C>T (y-axis) among COPD cases and controls (x-axis) (N = 1339, P = 0.043). Homozygotes were counted as carrying two and heterozygotes as carrying one copy of a given allele. b Differences in cg18825076 DNA methylation levels (y-axis) between rs12914385:C>T genotypes (x-axis) (N = 1489, P = 1.05 × 10⁻¹²⁵). c Differences in cg18825076 DNA methylation levels (y-axis) in COPD cases and controls (x-axis) (N = 1339, P = 0.04)