Table 3.
Cox proportional hazards regression model analysis of risk factors for second female genital cancers after breast cancer: adjusted hazard ratio (aHR) and 95% confidence interval (95% CI)
| Variables | Corpus uteri | Ovary | ||
|---|---|---|---|---|
| aHR (95% CI) | P value | aHR (95% CI) | P value | |
| Calendar year of breast cancer diagnosis | ||||
| 2000–2004 | Reference | Reference | ||
| 2005–2009 | 0.769 (0.704, 0.841) | < 0.001 | 1.321 (1.104, 1.580) | 0.002 |
| 2010–2014 | 0.711 (0.616, 0.820) | < 0.001 | 1.840 (1.277, 2.652) | 0.001 |
| Age at diagnosis | ||||
| ≤ 45 years | Reference | Reference | ||
| 46–55 years | 2.343 (1.990, 2.758) | < 0.001 | 1.146 (0.951, 1.382) | 0.153 |
| 56+ years | 3.218 (2.764, 3.746) | < 0.001 | 1.453 (1.231, 1.716) | < 0.001 |
| Race | ||||
| White | Reference | Reference | ||
| Black | 1.142 (1.005, 1.298) | 0.042 | 0.691 (0.555, 0.859) | 0.001 |
| American Indian/Alaskan Native | 0.558 (0.266, 1.173) | 0.124 | 0.783 (0.325, 1.886) | 0.586 |
| Asian or Pacific Islander | 1.072 (0.928, 1.239) | 0.346 | 0.962 (0.776, 1.194) | 0.727 |
| ER | ||||
| Negative | Reference | Reference | ||
| Positive | 0.928 (0.808, 1.066) | 0.293 | 0.655 (0.544, 0.788) | < 0.001 |
| PR | ||||
| Negative | Reference | Reference | ||
| Positive | 1.131 (1.004, 1.273) | 0.043 | 0.848 (0.715, 1.007) | 0.060 |
*P values calculated by Log-rank testing; bold if statistically significant, P < 0.05