Table 2.
Multivariable Cox models for any local recurrence
| Effect | ECOG 5194 | Ontario DCIS cohort | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| DCIS score/50 | 2.48 (1.29, 4.75) | 0.006 | 1.95 (1.14, 3.32) | 0.014 |
| Tumor size (cm) | ||||
| > 1–2.5 versus ≤ 1 | 1.45 (0.78, 2.69) | 0.24 | 1.47 (0.82, 2.64) | 0.19 |
| > 2.5 versus ≤ 1 | – | – | 2.99 (1.32, 6.76) | 0.009 |
| Age at diagnosis (years) | ||||
| ≥ 50 versus < 50 | 0.61 (0.33, 1.11) | 0.10 | 0.84 (0.48, 1.49) | 0.55 |
| Year of diagnosis | ||||
| 2000 or later versus before 1999 | 0.67 (0.38, 1.17) | 0.16 | 0.49 (0.28, 0.87) | 0.016 |