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. 2018 May 11;7(5):39. doi: 10.1038/s41389-018-0048-4

Fig. 7. CARF knockdown attenuates tumor metastases in xenograft models.

Fig. 7

a Schematic diagram showing regime of nude mice xenograft assays. b Tumor volumes of control, CARF-enriched, and CARF-compromised xenografts. c, Luciferase activity of orthotopic xenograft tumors in mice systemically treated with PBS, RdB, or RdB-shCARF; luciferase intensity and its scale bar are shown on the right. d Quantitation plot showing total flux (p/s) values (tumor size) retrieved from PBS, RdB, or RdB-shCARF groups on 7, 14, and 21 days. e Schematic model showing role of CARF in EMT progression, it stimulates nuclear localization of β-catenin instigating activation of several key transcription factors and gene targets that promote progression of EMT