Table 1.
Odds ratio (OR) with 95% confidence interval (95% CI) of developing ACPA positive and negative RA for different categories of smokers compared with never smokers
| Total | ACPA positive RA | ACPA negative RA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Total | ca/coa | OR (95% CI)b | OR (95% CI)d | ca/coa | OR (95% CI)b | OR (95% CI)d | ca/coa | OR (95% CI)b | OR (95% CI)e |
| Never | 1210/2655 | 1.0 (reference) | 1.0 (reference) | 730/2655 | 1.0 (reference) | 1.0 (reference) | 480/2655 | 1.0 (reference) | 1.0 (reference) |
| Past | 1332/1909 | 1.7 (1.5–1.8) | 1.7 (1.5–1.8) | 884/1909 | 1.7 (1.5–1.9) | 1.7 (1.5–2.0) | 448/1909 | 1.3 (1.1–1.5) | 1.3 (1.1–1.5) |
| Current | 1113/1319 | 1.9 (1.7–2.1) | 1.8 (1.6–2.0) | 785/1319 | 2.2 (1.9–2.5) | 2.1 (1.9–2.4) | 328/1319 | 1.4 (1.2–1.6) | 1.4 (1.2–1.6) |
| Ever | 2445/3228 | 1.5 (1.4–1.7) | 1.5 (1.4–1.7) | 1669/3228 | 1.9 (1.7–2.1) | 1.9 (1.7–2.1) | 776/3228 | 1.3 (1.2–1.5) | 1.3 (1.2–1.5) |
| Women | ca/coa | OR (95% CI)c | OR (95% CI)e | ca/coa | OR (95% CI)c | OR (95% CI)e | ca/coa | OR (95% CI)c | OR (95% CI)e |
| Never | 923/1956 | 1.0 (reference) | 1.0 (reference) | 574/1956 | 1.0 (reference) | 1.0 (reference) | 349/1956 | 1.0 (reference) | 1.0 (reference) |
| Past | 903/1290 | 1.5 (1.3–1.7) | 1.5 (1.3–1.7) | 606/1290 | 1.6 (1.4–1.8) | 1.6 (1.4–1.9) | 297/1290 | 1.3 (1.1–1.5) | 1.3 (1.1–1.5) |
| Current | 799/973 | 1.7 (1.5–2.0) | 1.7 (1.5–1.9) | 565/973 | 2.0 (1.7–2.3) | 1.9 (1.7–2.2) | 234/973 | 1.4 (1.1–1.6) | 1.4 (1.1–1.6) |
| Ever | 1702/2263 | 1.6 (1.4–1.8) | 1.6 (1.4–1.8) | 1171/2263 | 1.8 (1.6–2.0) | 1.8 (1.6–2.0) | 531/2263 | 1.3 (1.1–1.5) | 1.3 (1.1–1.5) |
| Men | ca/coa | OR (95% CI)c | OR (95% CI)e | ca/coa | OR (95% CI)c | OR (95% CI)e | ca/coa | OR (95% CI)c | OR (95% CI)e |
| Never | 287/699 | 1.0 (reference) | 1.0 (reference) | 156/699 | 1.0 (reference) | 1.0 (reference) | 131/699 | 1.0 (reference) | 1.0 (reference) |
| Past | 429/619 | 1.7 (1.4–2.1) | 1.7 (1.4–2.1) | 278/619 | 2.2 (1.7–2.7) | 2.1 (1.7–2.7) | 151/619 | 1.2 (0.9–1.6) | 1.2 (0.9–1.5) |
| Current | 314/346 | 2.2 (1.8–2.7) | 2.1 (1.7–2.6) | 220/346 | 2.9 (2.3–2.7) | 2.8 (2.2–3.5) | 94/346 | 1.5 (1.1–2.0) | 1.5 (1.0–1.9) |
| Ever | 743/965 | 1.9 (1.6–2.3) | 1.8 (1.5–2.2) | 498/965 | 2.5 (2.0–3.0) | 2.4 (1.9–2.9) | 245/965 | 1.3 (1.0–1.7) | 1.3 (1.0–1.7) |
aNumber of cases and controls
bAdjusted for age, gender, residential area, and study
cAdjusted for age, residential area, and study
dAdjusted for age, gender, residential area, study, ancestry, educational level, passive smoking, alcohol consumption, and body mass index at inclusion in the study
eAdjusted for age, residential area, study, ancestry, educational level, passive smoking, alcohol consumption, and body mass index at inclusion in the study