Table 3.
OR with 95% CI of developing ACPA positive RA and ACPA negative RA for smokers compared with never-smokers, by duration (years) and intensity of smoking (number of cigarettes smoked daily)
| ACPA positive RA | ||||||||
|---|---|---|---|---|---|---|---|---|
| Intensity Duration |
0 | < 10 | 10–20 | > 20 | ||||
| 0 | 730/2655 | 1.0 (reference) | ||||||
| 0–10 | 77/268 | 1.0 (0.8–1.2) | 78/262 | 1.4 (1.2–1.8) | 264/257 | 1.6 (1.3–2.1) | ||
| 11–19 | 68/222 | 1.2 (0.9–1.7) | 126/311 | 1.6 (1.2–2.2) | 555/777 | 1.7 (1.2–2.4) | ||
| 20– | 34/109 | 2.8 (2.3–3.4) | 74/188 | 2.9 (2.5–3.4) | 325/476 | 2.8 (2.3–3.3) | ||
| ACPA negative RA | ||||||||
|---|---|---|---|---|---|---|---|---|
| Intensity Duration |
0 | < 10 | 10–20 | > 20 | ||||
| 0 | 480/2655 | 1.0 (reference) | ||||||
| 0–10 | 52/268 | 1.1 (0.8–1.5) | 57/262 | 1.0 (0.7–1.2) | 128/457 | 0.9 (0.6–1.2) | ||
| 11–19 | 34/222 | 1.3 (0.9–1.9) | 76/311 | 1.3 (0.9–1.9) | 200/777 | 1.3 (0.8–2.0) | ||
| 20– | 12/109 | 1.6 (1.3–2.1) | 128/188 | 1.6 (1.3–2.0) | 134/476 | 1.6 (1.2–2.0) | ||
Adjusted for age, gender, residential area, study, ancestry, educational level, passive smoking, alcohol consumption, and body mass index at inclusion in the study