Table 1.

Modulators of the TLR2/1 signaling pathway.

Inhibitor	Target	References
MicroRNAs
miR-UL112-3p	TLR2	Vo et al., 2005
miR-K5	IRAK1	Xiao and Rajewsky, 2009
miR-K9	MyD88	Xiao and Rajewsky, 2009
miR-143	TLR2 and NF-κB	Krichevsky et al., 2003; Wayman et al., 2008
miR-132	IRAK4	Abend et al., 2012
miR-21	MyD88 and IRAK1	O'Neill et al., 2011
miR-146a	TRAF6 and IRAK1	Chen et al., 2013a; Guo et al., 2013; Landais et al., 2015; Liu et al., 2015
miR-124	TRAF6	Taganov et al., 2006; Nahid et al., 2013
miR-92a	MKK4	Meisgen et al., 2014
miR-147 miR-7116-5p	Unknown TNFα	Saba et al., 2012; Ma et al., 2014; Santra et al., 2014
miR-155	SOCS1 and SHIP1	Liu et al., 2009; Zhang et al., 2016
NATURAL COMPOUNDS
Methylpenicinoline	Unknown	Strassheim et al., 2005
Calcitriol	miR-155	Nakagawa et al., 2002
Schizandrin A/B	Unknown	Aravalli et al., 2008; Aslanidis et al., 2015; Koymans et al., 2015
Gomosins A/G/J/N Pristimerin	Nrf2 IRAK1 and TRAF6	Chen et al., 2013b; Kim et al., 2014
Deoxysappone B	Unknown	Song et al., 2016
Sparstolonin B	MyD88	Park et al., 2014
Daphnetin	A20	Kumar et al., 2016
Curcurbitacin B/E/I	Nrf2	Liu et al., 2016
Kolaviron	Nrf2	Yao et al., 2011
Pseudoginsenoside-F11	MyD88	Park et al., 2015
SYNTHETIC COMPOUNDS
CU-CPT22	TLR2/1	Arel-Dubeau et al., 2015; Olajide et al., 2017
RSCL-0409	MyD88	Oyagbemi et al., 2017
C16H15NO4 (C29)	MyD88	Wang et al., 2014
Ortho-vanillin	MyD88	Wang et al., 2014
M2000	Unknown	Kalluri et al., 2010; Mistry et al., 2015
G2013	Unknown/Tollip	Afraei et al., 2015; Mirshafiey et al., 2016; Aletaha et al., 2017
NG25	TAK1	Pourgholi et al., 2017
MRT67307	TBK1 and IKKε	Jahromi et al., 2017
BMS345541	IKKβ	Nazeri et al., 2017
MCAP	Unknown	Hajivalili et al., 2016
Bay-11-708	NF-κB	Sharifi et al., 2017
Candesartan	Angiotensin II receptor	Pauls et al., 2012
Fasudil	Rho kinase	Yang et al., 2006; Clark et al., 2011
cRGD	MFG-E8 receptor	Matteucci et al., 2015