Fig. 7. Hepatic fat infiltration is attributable to the vicious cycle of ER stress, mitochondrial dysregulation and cell damage in HFD burned mice.

Hepatic ER stress and disturbed ER–mitochondria communication lead to the derangement of mitochondrial ETC activities, energy production, and impaired lipid metabolism. This contributes to the increased hepatic fat infiltration, which, together with hepatic inflammasome activation, results in increased liver damage in HFD burned mice