Table 1.
Host range spectrum of thebacteriophage vB_EcoS-B2.
| E. coli strain | Source | Subtype | Resistance | Lysis or not |
|---|---|---|---|---|
| E. coli K-12 MG1655 | Clear plaque | |||
| E. coli TOP10 | Clear plaque | |||
| E. coli S17-1 | Clear plaque | |||
| E. coli DH5α | Clear plaque | |||
| E. coli BW25113 | Clear plaque | |||
| E. coli BL21(DE3) | Clear plaque | |||
| E. coli JM110 | N | |||
| 25922 | ATCC 25922 | Non-ESBL | N | |
| 35218 | ATCC 35218 | ESBL | Turbid plaque | |
| 389 A6 | Urine | ESBL | Aztreonam, cefazolin, ceftazidime, cefatriaxone, sulfamethoxazole, and trimethoprim | Turbid plaque |
| 389 A9 | pus and secretion | ESBL | Aztreonam, cefazolin, ceftazidime, sulfamethoxazole, and trimethoprim | N |
| 389 D9 | Urine | Non-ESBL | Sulfamethoxazole and trimethoprim | N |
| 389 E6 | Urine | Non-ESBL | Levofloxacin | N |
| 389 G4 | Urine | Non-ESBL | Amikacin, Ampicillin sulbactam, aztreonam, cefazolin, cefepime, cefotaxime, cefoxitin, ceftazidime, gentamycin, Levofloxacin, | N |
| 389 G6 | Urine | Non-ESBL | Levofloxacin | N |
| 389 G7 | Urine | ESBL | Amikacin, Ampicillin sulbactam, aztreonam, cefazolin, cefotaxime, Levofloxacin | N |
| 389 J4 | Sputum | ESBL | Aztreonam, cefazolin, cefepime, ceftazidime, cefatriaxone, | N |
| 390 A7 | Sputum | Non-ESBL | Sulfamethoxazole and trimethoprim | N |
| 390 B6 | Urine | Non-ESBL | Sulfamethoxazole and trimethoprim | N |
| 390 G7 | Urine | Non-ESBL | Ampicillin sulbactam, cefazolin, gentamycin, Levofloxacin, sulfamethoxazole, and trimethoprim | Clear plaque |
| 390 H2 | Urine | Non-ESBL | Ampicillin sulbactam, cefazolin, gentamycin, Levofloxacin, sulfamethoxazole, and trimethoprim | N |
| 390 J2 | Urine | Non-ESBL | Levofloxacin, minocycline, sulfamethoxazole, and trimethoprim | N |
| 391 D3 | Urine | Non-ESBL | Cefazolin, gentamycin, sulfamethoxazole, and trimethoprim | N |
| 391 G4 | Blood | ESBL | Aztreonam, cefazolin, cefepime, ceftazidime, cefatriaxone, | N |
| 393 B7 | Urine | ESBL | Amikacin, amoxicillin and clavulanate, Ampicillin sulbactam, aztreonam, cefazolin, cefepime, cefotaxime, cefoxitin, ceftazidime, gentamycin, Levofloxacin, minocycline, sulfamethoxazole, and trimethoprim | N |
| 393 C1 | Ascites | ESBL | Ampicillin sulbactam, aztreonam, cefazolin, cefepime, cefotaxime, ceftazidime, gentamycin, sulfamethoxazole and trimethoprim | Clear plaque |
| 393 C8 | Urine | ESBL | Cefazolin, cefepime, cefotaxime, Levofloxacin, sulfamethoxazole, and trimethoprim | N |
| 393 D3 | Urine | ESBL | Cefazolin, cefepime, cefotaxime, ceftazidime, Levofloxacin, | N |
| 394 F7 | Urine | ESBL | Amoxicillin and clavulanate, aztreonam, cefazolin, cefotaxime, cefoxitin, ceftazidime | N |
| 394 G1 | Urine | ESBL | Amoxicillin and clavulanate, cefazolin, cefoxitin, imipenem, sulfamethoxazole, and trimethoprim | N |
| 394 H7 | Urine | ESBL | Aztreonam, cefepime, cefotaxime, ceftazidime, Levofloxacin | Clear plaque |
| 395 B5 | Urine | ESBL | Ampicillin sulbactam, aztreonam, cefazolin, cefepime, cefotaxime, gentamycin, Levofloxacin, sulfamethoxazole, and trimethoprim | N |
| 395 G6 | Urine | ESBL | Aztreonam, cefazolin, cefepime, cefotaxime, ceftazidime, gentamycin | N |
| 395 J2 | Sputum | ESBL | Ampicillin, gentamycin, Levofloxacin, minocycline | N |
| 396 F3 | Sputum | ESBL | Amikacin, ampicillin, gentamycin, Levofloxacin, minocycline | Clear plaque |
| 396 J1 | Urine | ESBL | Cefazolin, cefepime, cefotaxime, imipenem, Levofloxacin, | N |
| 396 J5 | Urine | ESBL | Aztreonam, cefazolin, cefepime, cefotaxime, imipenem, Levofloxacin | N |
| 397 C8 | Sputum | ESBL | Aztreonam, cefazolin, cefepime, ceftazidime, cefatriaxone | N |
| 397 D3 | Urine | ESBL | Ampicillin sulbactam, aztreonam, cefazolin, cefepime, cefotaxime, cefoxitin, gentamycin, Levofloxacin, sulfamethoxazole, and trimethoprim | N |
| 37 | n.d | NDM-5 | Ampicillin/Sulbactam, aztreonam, imipenem, Levofloxacin, piperacillin, Cefuroxime sodium, cefuroxime axetil, sulfamethoxazole, and trimethoprim, ceftazidime, Tazobactam, Meropenem, cefotetan, cefatriaxone, cefazolin, Cefepime plaster | N |
| 40 | n.d | NDM-5 | Ampicillin/Sulbactam, amikacin, aztreonam, gentamycin, imipenem, Levofloxacin, piperacillin, Cefuroxime sodium, cefuroxime axetil, sulfamethoxazole and trimethoprim, ceftazidime, Tazobactam, tobramycin, Meropenem, cefotetan, cefatriaxone, cefazolin, Cefepime plaster | N |
| 64 | n.d | NDM-5 | Ampicillin/Sulbactam, gentamycin, imipenem, Levofloxacin, piperacillin, Cefuroxime sodium, cefuroxime axetil, sulfamethoxazole and trimethoprim, ceftazidime, Tazobactam, tobramycin, Meropenem, cefotetan, cefatriaxone, cefazolin, Cefepime plaster | N |
| 69 | n.d | NDM-5 | Ampicillin/Sulbactam, amikacin, aztreonam, gentamycin, imipenem, Levofloxacin, piperacillin, Cefuroxime sodium, cefuroxime axetil, sulfamethoxazole and trimethoprim, ceftazidime, Tazobactam, tobramycin, Meropenem, cefotetan, cefatriaxone, cefazolin, Cefepime plaster | N |
| 92 | n.d | NDM-5 | Ampicillin/Sulbactam, gentamycin, imipenem, Levofloxacin, piperacillin, Cefuroxime sodium, cefuroxime axetil, sulfamethoxazole and trimethoprim, ceftazidime, Tazobactam, tobramycin, Meropenem, cefotetan, cefatriaxone, cefazolin, Cefepime plaster | Turbid plaque |
Positive results are indicated by “Clear plaque” or “Turbid plaque,” and negative results are indicated by “N”; n.d., no data available; In the column “subtype,” “ESBL” represent “Extended-Spectrum Beta Lactamase,” “NDM-5” represent “New Delhi metallo-β-lactamase-5.”