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. 2018 May 10;8:7472. doi: 10.1038/s41598-018-25913-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cavitation-threshold measurements for two types of bubbles at frequencies of 3.34 MHz (top) and 5.39 MHz (bottom). Error bars represent standard deviation of CI over 10 measurements for each pressure level. The blue and red dashed lines (for Albumin NBs and Sonazoid MBs, respectively) represents the pressure interval that is assumed to comprise the cavitation threshold. The asterisk states a statistically the lower pressure parameter with a significant difference relatively to the CI in degassed water (p < 0.01) (it is not displayed for higher pressures for figure clarity).