Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 6;5(5):583–597. doi: 10.1002/acn3.559

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Voxel‐wise associations of grey matter deficits with higher NfL levels. (A) Widespread regions including ventral and dorsomedial prefrontal cortex, ventral and dorsal insula, anterior cingulate, caudate, and medial thalamus showed lower grey matter volume (voxel‐wise analysis) associated with higher NfL levels. Significant clusters were defined at a t‐threshold of P < 0.001 uncorrected (blue‐green colored) and p _fwe < 0.05 (red colored). Color bars represent t‐scores, and statistical maps are superimposed on the Montreal Neurological Institute template brain. The left side of the axial and coronal images corresponds to the left (L) side of the brain. (B) Mean grey matter intensity versus log‐transformed NfL levels within the P < 0.001 map in (A), for 24 presymptomatic C9orf72 expansion carriers (grey dots), 4 mild impairment (orange dots), 17 bvFTD (pink dots), 4 bvFTD‐MND (green dots), and 1 PPA (purple dot) plotted for visualization purposes only. Both presymptomatic (C) and symptomatic carriers (D) show associations of NfL with grey matter atrophy in bilateral dorsolateral prefrontal cortex, parietal regions, and caudate. Symptomatic carriers (D) additionally show grey matter atrophy associated with NfL in key hubs targeted in bvFTD, including anterior and mid cingulate cortex and insula.