Table 2.
Sample size estimation according to ITS changes and Q Alb strata
| Q Alb (×10−3) | ||||
|---|---|---|---|---|
| 2 | 4 | 6 | 10 | |
| IgGLoc SDa (mg/L) | 1.7 | 3.5 | 4.9 | 8.7 |
| Estimated sample size for ITS variation of: | ||||
| 1 mg/L | 93 | 387 | 756 | 2379 |
| 5 mg/L | 7 | 18 | 33 | 98 |
| 10 mg/L | 4 | 7 | 10 | 26 |
| IgG index (SD) | ||||
| Basal | 0.42 (0.08) | 0.45 (0.08) | 0.48 (0.08) | 0.52 (0.08) |
| +ITS 10 mg/L | 0.94 (0.16) | 0.69 (0.1) | 0.65 (0.08) | 0.62 (0.08) |
| Estimated sample size: | 6 | 7 | 10 | 23 |
Sample size is estimated to detect a difference with a power of 80% at P = 0.05.
a
SD of IgGLoc are similar whatever the level of basal ITS.