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. 2018 Apr 2;5(5):616–629. doi: 10.1002/acn3.560

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Analysis of GRN promoter and gene body DNA (CpG) methylation in DNA from peripheral blood. (A–B) lack of difference in promoter (A) or gene body (B) methylation between AD and control patients. n = 355, Welch's t‐test. (C) GRN promoter methylation is significantly lower in males compared with females across diagnostics categories. Welch's t‐test. (D) GRN gene body methylation decreases with age. Linear regression. All analysis performed with the UCSF‐MAC cohort. (A‐C) standard boxplot representing median and IQR, whiskers represent 1.5 IQR greater or less than the upper and lower quartile. (D) scatterplot with line of best‐fit. **P < 0.01, n.s. P>0.05.