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. 2018 May 1;9:470. doi: 10.3389/fphys.2018.00470

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Copyright © 2018 Liu, Jin, Li, Zhao, Li, Xu, Zhao, Feng, Chen, Fang, Shilpakar and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbiota study in LC patients and HC. (A) PCoA analysis based on Bray_Curtis distance between HC and LC [Pr(>F) = 0.0068, pMANOVA], Child_5 and Child_5+ sub-group in LC [Pr(>F) = 0.24, pMANOVA]. (B) F/B ratio and (C) MDI comparison between groups. Boxes represented the 25 to75th percentile of the distribution; the median was shown as a thick line in the middle of the box; whiskers extend to values with 1.5 times the difference between the 25th and 75th percentiles, Wilcoxon rank-sum test, ^∗∗p < 0.01. (D) Comparisons of the relative bacterial abundance at phylum, family and genus levels in LC and HC, Wilcoxon rank-sum test, multiple hypothesis tests were adjusted for comparison and only hypothesis tests got p_fdr < 0.05 were displayed. HC (n = 20), LC (n = 36, Child_5, n = 25; Child_5+, n = 11).