Table 2.

Multivariable binary logistic regression analysis of risk factors for small vessel disease.

	Age		Male		Diabetes mellitus		Hypertension		CKD
	OR	p-Value	OR	p-Value	OR	p-Value	OR	p-Value	OR	p-Value
WMH, overall	1.060 (1.024–1.098)	0.001	3.457 (1.241–9.630)	0.018	1.373 (0.489–3.853)	n.s.	1.186 (0.262–5.367)	n.s.	1.695 (0.869–3.303)	n.s.
WMH, periventricular	1.052 (1.018–1.088)	0.002	3.847 (1.419–10.426)	0.008	1.148 (0.419–3.146)	n.s.	1.179 (0.264–5.268)	n.s.	1.480 (0.781–2.806)	n.s.
WMH, deep	1.059 (1.026–1.092)	<0.001	2.746 (1.213–6.219)	0.015	0.787 (0.317–1.950)	n.s.	0.989 (0.208–4.702)	n.s.	1.848 (1.022–3.343)	0.042
EPVS, overall	1.044 (1.001–1.088)	0.044	2.543 (0.643–10.052)	n.s.	0.909 (0.226–3.659)	n.s.		n.s.	0.771 (0.346–1.717)	n.s.
EPVS, centrum semiovale	1.055 (1.022–1.088)	0.001	1.026 (0.449–2.343)	n.s.	0.730 (0.280–1.899)	n.s.	1.352 (0.329–5.559)	n.s.	1.411 (0.777–2.565)	n.s.
EPVS, basal ganglia	1.049 (1.008–1.092)	0.018	2.125 (0.611–7.394)	n.s.	0.789 (0.199–3.128)	n.s.		n.s.	0.938 (0.433–2.032)	n.s.
CMB, overall	1.027 (0.998–1.058)	0.071	1.247 (0.572–2.718)	n.s.	0.806 (0.337–1.927)	n.s.	0.913 (0.204–4.087)	n.s.	2.628 (1.462–4.724)	0.001
CMB, lobar	1.024 (0.991–1.057)	n.s.	1.953 (0.838–4.555)	n.s.	1.656 (0.618–4.442)	n.s.	1.369 (0.242–7.741)	n.s.	2.106 (1.119–3.963)	0.021
CMB, deep	1.023 (0.994–1.053)	n.s.	0.948 (0.437–2.056)	n.s.	0.858 (0.362–2.037)	n.s.	0.545 (0.103–2.876)	n.s.	2.237 (1.263–3.960)	0.006
Lacune, overall	1.011 (0.981–1.043)	n.s.	0.819 (0.360–1.866)	n.s.	0.648 (0.272–1.543)	n.s.	1.978 (0.483–8.091)	n.s.	1.063 (0.590–1.913)	n.s.
Lacune, lobar	1.012 (0.976–1.049)	n.s.	1.066 (0.415–2.742)	n.s.	0.744 (0.275–2.011)	n.s.	1.430 (0.259–7.903)	n.s.	1.258 (0.637–2.482)	n.s.
Lacune, deep	0.996 (0.952–1.043)	n.s.	0.617 (0.160–2.382)	n.s.	0.507 (0.137–1.873)	n.s.		n.s.	0.916 (0.374–2.244)	n.s.

CKD, chronic kidney disease; WMH, white matter hyperintensity; EPVS, enlarged perivascular spaces; CMB, cerebral microbleed.