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. 2018 May 4;9:503. doi: 10.3389/fphys.2018.00503

Figure 4.

Figure 4

Evaluation of miR-21−/− mice modeled by CS exposure + CSE injection. (A) Level of miR-21 in miR-21−/− mice lung. (B) Trends of mice body weight gain during modeling days of different group. (C) Lung functions of mice in different group. (D) H&E staining of lung tissue from GC (100X). (E) H&E staining of lung tissue from NCM (100X), exhibited enlarged alveolar space, thinner alveolar septum, and destroyed alveolar wall when compared with CG (D,F) H&E staining of miR-21−/− CS+CSE group (100X), exhibited moderately enlarged alveolar space, thinner alveolar septum, and destroyed alveolar wall when compared with CG (D), but lighter than NCM (E). (G) Changes of mean alveolar septal thickness (MAST); (H) changes of mean linear intercept (MLI); (I) changes of destructive index (DI). *Compared with control group, p < 0.05; **compared with control group, p < 0.001; &compared with WT CS+CSE group, p < 0.05; &&compared with WT CS+CSE group, p < 0.001. Scale bars: 200 um. Error bars: mean ± SEM. n = 5.