Table 3.
Frequency of Test Findings and Association With Clinical Events for Anatomic and Functional Testing*
| Initial Test Results | Anatomic Testing (N=4500) | Functional Testing (N=4602) | ||||||
|---|---|---|---|---|---|---|---|---|
| Frequency n/N (%) |
Event Rate n/N (%) |
HR (95% CI) | P Value | Frequency n/N (%) |
Event Rate n/N (%) |
HR (95% CI) | P Value | |
| All-cause death/myocardial infarction/unstable angina | ||||||||
| Severely abnormal | 266/4500 (5.91) | 28/266 (10.53) | 10.13 (5.15–19.92) | <0.0001 | 365/4602 (7.93) | 35/365 (9.59) | 3.88 (2.58–5.85) | <0.0001 |
| Moderately abnormal | 268/4500 (5.96) | 21/268 (7.84) | 7.67 (3.83–15.37) | <0.0001 | 217/4602 (4.72) | 13/217 (5.99) | 2.65 (1.46–4.83) | 0.0014 |
| Mildly abnormal | 2461/4500 (54.69) | 74/2461 (3.01) | 2.94 (1.64–5.26) | 0.0003 | 432/4602 (9.39) | 9/432 (2.08) | 0.94 (0.47–1.89) | 0.8666 |
| Normal | 1505/4500 (33.44) | 14/1505 (0.93) | 3588/4602 (77.97) | 75/3588 (2.09) | ||||
| Cardiovascular death/myocardial infarction/unstable angina | ||||||||
| Severely abnormal | 266/4500 (5.91) | 26/266 (9.77) | 17.26 (7.55–39.46) | <0.0001 | 365/4602 (7.93) | 31/365 (8.49) | 4.59 (2.93–7.19) | <0.0001 |
| Moderately abnormal | 268/4500 (5.96) | 18/268 (6.72) | 12.03 (5.14–28.19) | <0.0001 | 217/4602 (4.72) | 13/217 (5.99) | 3.50 (1.89–6.48) | <0.0001 |
| Mildly abnormal | 2461/4500 (54.69) | 57/2461 (2.32) | 4.08 (1.93–8.66) | 0.0002 | 432/4602 (9.39) | 8/432 (1.85) | 1.11 (0.53–2.34) | 0.7834 |
| Normal | 1505/4500 (33.44) | 8/1505 (0.53) | 3588/4602 (77.97) | 56/3588 (1.56) | ||||
| Cardiovascular death/myocardial infarction | ||||||||
| Severely abnormal | 266/4500 (5.91) | 9/266 (3.38) | 4.87 (1.72–13.75) | 0.0028 | 365/4602 (7.93) | 14/365 (3.84) | 2.13 (1.16–3.91) | 0.0141 |
| Moderately abnormal | 268/4500 (5.96) | 5/268 (1.87) | 3.09 (0.96–9.97) | 0.0594 | 217/4602 (4.72) | 5/217 (2.30) | 1.53 (0.60–3.90) | 0.3681 |
| Mildly abnormal | 2461/4500 (54.69) | 39/2461 (1.58) | 2.73 (1.20–6.25) | 0.0170 | 432/4602 (9.39) | 5/432 (1.16) | 0.81 (0.32–2.04) | 0.6542 |
| Normal | 1505/4500 (33.44) | 7/1505 (0.47) | 3588/4602 (77.97) | 48/3588 (1.34) | ||||
CI indicates confidence interval; and HR, hazard ratio. Nonobstructive coronary artery disease is defined as 1% to 69% of stenosis.
*
Secondary test result stratification sets computed tomographic angiography threshold for moderate abnormality to 70%.