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. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: Eur J Med Chem. 2017 Mar 19;132:184–191. doi: 10.1016/j.ejmech.2017.03.026

Fig. 5.

Fig. 5

Surface representation of ureido-substituted benzenesulfonamide compounds bound to the active site of A) hCA II (grey) and B) hCA IX-mimic (cyan). Compound U-CH3 (pink), c U-F (green), and U-NO2 (yellow). Zinc (magenta sphere), hydrophilic (blue) and hydrophobic (orange) residues are as shown. Red double-headed arrows indicate isoform specificity relative to residue 131 (labeled in black). The Ki values of each compound bound to hCA II and hCA IX are also labeled. The figure was made using PyMol.26. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)