Table 2.

Inhibition and isozyme selectivity ratio for hCA II, IX, and XII with ureido-substituted benzenesulfonamide compounds U-CH₃, U-F, and U-NO₂.

Compound	Ki (nM)a			Selectivity Ratiob
	hCA II	hCA IX	hCA XII	II/IX	II/XII	IX/XII	XII/IX
U-CH3	1765	7	6	250	300	1	1
U-F	960	45	4	20	240	10	<1
U-NO2	15	1	6	15	2	<1	5

^aK_i values obtained from Pacchiano et al., [11]: U-CH₃ (3,5-Me₂C₆H₃), U-F (4-FC₆H₄), U-NO₂ (3-O₂NC₆H₄).

^bSelectivity as determined by the ratio of K_is for hCA isozyme relative to hCA IX and hCA XII.