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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Arch Pathol Lab Med. 2018 Feb 19;142(5):613–625. doi: 10.5858/arpa.2017-0181-OA

Figure 2.

Figure 2

Example of classes and subclasses of descriptors (images) and how they are organized in the modified Nephrotic Syndrome Study Network Digital Pathology Scoring System (NDPSS), NDPSS1, and NDPSS2. The NDPSS2 class any sclerosis, wrinkling, or tip includes the subclasses any sclerosis (A and B) and any wrinkling (C and D). The NDPSS2 subclass any sclerosis contains additional subclasses global sclerosis (A) and segmental sclerosis (C); the NDPSS2 subclass any wrinkling contains additional subclasses global wrinkling (C) and segmental wrinkling (D). The NDPSS1 and 2 class global obliteration includes the subclasses global sclerosis (A) and global wrinkling (C); the NDPSS1 and 2 class segmental obliteration includes the subclasses segmental sclerosis (C) and segmental wrinkling (D). Examples of descriptors in the various classes and subclasses: A, The descriptors global sclerosis with hyalinosis (periodic acid–Schiff) and obsolescence (hematoxylin-eosin) are grouped in the NDPSS1 and 2 subclass global sclerosis, the NDPSS2 subclass any sclerosis, and the NDPSS1 and 2 class global obliteration. B, The descriptors segmental sclerosis away from vascular and tubular pole (silver stain), tip lesion (silver stain; yellow arrows), and segmental perihilar sclerosis (periodic acid–Schiff; blue arrow) are grouped in the NDPSS1 and 2 subclass segmental sclerosis, the NDPSS2 subclass any sclerosis, and the NDPSS1 and 2 class segmental obliteration. C, The descriptors global collapse (trichrome) and global deflation (silver stain) are grouped in the NDPSS1 and 2 subclass global wrinkling, the NDPSS2 subclass any wrinkling, and the NDPSS1 and 2 class global obliteration. D, The descriptors segmental collapse (silver stain; green arrows) and segmental deflation (periodic acid–Schiff; red arrows) are grouped in the NDPSS1 and 2 subclass segmental wrinkling, the NDPSS2 subclass any wrinkling, and the NDPSS1 and 2 class segmental obliteration. The descriptors global collapse and segmental collapse are also grouped in the NDPSS2 any collapse, and the descriptors global deflation and segmental deflation are also grouped in the NDPSS2 subclass any deflation (not shown in figure) (original magnifications ×60 [A, global sclerosis with hyalinosis] and ×40 [A, obsolescence, and B through D]).