Table 1.

Groupings of Individual Descriptors Into Classes Included in Each Set of Scoring Strategies

	Classes
	Any Sclerosis, Wrinkling, or Tip	Global Obliteration	Segmental Obliteration	Podocyte Injury	Mesangiopathic Changes	GBM Spikes
Individual descriptor
No/minimal changes
Global sclerosis with hyalinosis	X	X
Global sclerosis without hyalinosis	X	X
Global collapse	X	X
Global deflation	X	X
Obsolescence	X	X
Global mesangial sclerosis		X
Segmental perihilar sclerosis	X		X
Segmental extended perihilar sclerosis	X		X
Segmental sclerosis away from vascular and tubular pole	X		X
Segmental sclerosis cannot determine location	X		X
Cellular tip lesion	X		X
Sclerosing tip lesion	X		X
Extended cellular tip lesion	X		X
Extended sclerosing tip lesion	X		X
Midglomerular sclerosis			X
Cellular nontip	X		X
Segmental collapse	X		X
Segmental deflation	X		X
Periglomerular fibrosis
Glomerular foam cells			X
Segmental podocyte hyaline dropletsa				X
Global podocyte hyaline dropletsa				X
Hyalinosis at the vascular pole			X
Hyalinosis at the tubular pole			X
Hyalinosis away from vascular and tubular pole			X
Hyalinosis cannot determine location			X
Synechia			X
Segmental podocyte hypertrophy				X
Global podocyte hypertrophy				X
Segmental podocyte hyperplasia				X
Global podocyte hyperplasia				X
Halo				X
Segmental mesangial expansion					X
Global mesangial expansion					X
Segmental mesangial cell proliferation					X
Global mesangial cell proliferation					X
Segmental spikes						X
Global spikes						X
Marginating leukocytes
Set of Scoring Strategies
Original NDPSSb	D	D	D	D	D	D
NDPSS1		P	P	P	P	P%
NDPSS2	D	D	D	D	D	D

Abbreviations: D, dichotomous; GBM, glomerular basement membrane; NDPSS, Nephrotic Syndrome Study Network Digital Pathology Scoring System; P, probability; %, percentage.

^aPodocyte hyaline droplets was originally scored as a single descriptor and split into 2 individual descriptors (global versus segmental) for the NDPSS1 only.

^bPostscoring grouping into classes.