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. 2018 Apr 1;17(3):e12759. doi: 10.1111/acel.12759

Figure 4.

Figure 4

Antileukotriene therapy ameliorates synaptic integrity and neuroinflammation in P301S transgenic mice. Starting at 3 months of age, P301S mice were randomized to receive zileuton or vehicle until 10 months of age and then euthanized, and brain was extracted for biochemistry. (a) Representative Western blot analyses for synaptophysin (SYP), postsynaptic density protein 95 (PSD95), and microtubule‐associated protein‐2 (MAP2) in brain cortex homogenates from P301S and P301S‐zileuton mice. (b) Densitometric analyses of the immunoreactivities shown in the previous panel (*p < .001) (n = 6 per group). (c) Representative Western blot analyses for glial fibrillary acidic protein (GFAP) and cluster domain (CD) 45 in brain cortex homogenates from P301S and P301S‐zileuton mice. (d) Densitometric analyses of the immunoreactivities to the antibodies from the previous panel (*p < .01) (n = 6 per group). Values represent mean ± SEM