Figure 1.

Global and region‐specific changes in DNA methylation with age. (a) Mean of the increasing and accelerating sites with the best model: $\text{age}\sim {\text{methylation}}^{-\frac{1}{3}}$. (b) Mean of the decreasing and accelerating sites with the best model: $\text{age}\sim {\text{methylation}}^{-\frac{1}{3}}$. (c) Linear regression slope of CpG sites that changed with age based on their assignment to indicated regions of the genome. (d) Enrichment analysis of significantly changing sites in indicated genomic regions. (e) Boxplot of the average methylation fraction across lifespan for all (All), gaining (Gain) and losing (Lose) methylation sites