Table 1.
Demographic data and the neuropathological assessment of the individuals included in the study
| Clinical diagnosisa | Gender | Age (years) | Neuropat. Ev (NFT/Aβ/LB)b | APOE genotype | Cause of death | Severe CVD |
|---|---|---|---|---|---|---|
| NC | F | 75 | 1/A/0 | 2/3 | Euthanasia | + |
| NC | F | 60 | 0/O/0 | 3/2 | Metastasized breast cancer | − |
| NC | M | 55 | 0/O/0 | 3/3 | Euthanasia with oesophageal cancer | − |
| NC | M | 75 | 1/A/0 | 3/3 | Cardiac arrest with COPD | + |
| NC | F | 84 | 2/B/0 | 3/3 | Pulmonary dysfunction | − |
| NC | F | 72 | 1/A/0 | 3/3 | Euthanasia, met. ovarian cancer | − |
| NC | F | 75 | 1/0/0 | 3/3 | Euthanasia | − |
| NC | M | 81 | 3/C/0 | 4/3 | Pancreas carcinoma | − |
| NC | M | 102 | 3/A/0 | 4/3 | Ileus | + |
| NC | F | 92 | 3/0/1 | 4/3 | Heart failure | + |
| NC | M | 70 | 1/0/3 | 3/3 | Pneumonia | + |
| NC | F | 68 | 0/0/0 | 3/3 | Euthanasia | − |
| AD | F | 91 | 4/C/0 | 3/3 | Cerebrovascular accident | − |
| AD | M | 85 | 4/C/0 | 3/3 | Cardiac arrest | + |
| AD | F | 96 | 4/B/0 | 3/3 | Heart failure, dementia | + |
| AD | F | 87 | 4/C/0 | 3/3 | Pneumonia | + |
| AD | M | 83 | 3/B/0 | 4/3 | Dehydration, AD | + |
| AD | F | 88 | 5/C/0 | 3/4 | Pneumonia | − |
| AD | F | 78 | 6/C/0 | 3/4 | Cachexia, Dementia | + |
| AD | M | 82 | 5/C/0 | 3/4 | AD with delirium | + |
| AD | M | 69 | 6/C/0 | 4/3 | Pneumonia | − |
| AD | F | 92 | 6/C/0 | 4/3 | Atrioventricular block, severe AD | + |
| AD | F | 70 | 6/C/0 | 4/4 | Cachexia by dementia | + |
| AD | F | 64 | 4/C/0 | 4/4 | Euthanasia, AD | − |
| AD | F | 71 | 5/C/0 | 4/3 | Dehydration, cachexia, dementia | + |
F, female; M, male; Severe CVD, cardiovascular disease.
a
Individuals clinically diagnosed with Alzheimer's disease (AD) and nondemented controls (NC) included in the study.
b
Braak staging of neurofibrillary tangles (NFT) and Lewy bodies (LB) and ABC staging of amyloid (Aβ).