Table 1.

Enrichment of various gene categories among genes differentially expressed with age

Dataset	Expression with age	GenAge	Genome maintenance	Germline	Neoblasts
Macrostomum lignano a	Down‐Down‐Down	ns	ns	ns	ns
	Down‐Down‐Up	ns	ns	0.13	0.15
	Down‐Up‐Down	ns	ns	0.49	ns
	Down‐Up‐Up	1.38	1.51	0.25	3.72
	Up‐Down‐Down	ns	ns	5.94	0.24
	Up‐Down‐Up	ns	ns	ns	0.3
	Up‐Up‐Down	ns	ns	ns	ns
	Up‐Up‐Up	ns	ns	ns	ns
	Increased at 26M vs. 2M	1.36	ns	0.58	2.93
	Decreased at 26M vs. 2M	0.75	0.46	1.49	0.07
C. elegans b	Increased at D10 vs. D3	0.61	0.45
	Decreased at D10 vs. D3	ns	ns
Mouse intestinal	Increased at 20M vs. 2M	ns	0.23
Stem cellsc	Decreased at 20M vs. 2M	ns	ns
Mouse liverd	Increased at 21M vs. 3M	ns	0.41
	Decreased at 21M vs. 3M	ns	ns
Mouse skine	Increased at 30M vs. 2M	ns	0.39
	Decreased at 30M vs. 2M	0.74	ns
Zebrafish skine	Increased at 42M vs. 5M	0.66	0.41
	Decreased at 42M vs. 5M	ns	1.47

ns, not significant.

^aThis study.

^bRangaraju et al., 2015.

^cNalapareddy et al., 2017.

^dBochkis et al., 2014.

^eMansfeld et al., 2015.