Figure 5.

Model for the sex‐specific regulation of aging in C. elegans. TRA‐1, the terminal transcription factor of the nematode sex‐determination pathway, promotes the expression of daf‐16 (d/f and a isoforms) to extend lifespan and to promote dauer development in hermaphrodites. As TRA‐1 is essentially active only in hermaphrodites, hermaphrodites live significantly longer than males. “IIS” denotes insulin/IGF‐1 signaling. Arrows indicate activations, and the bar represents inhibitory regulatory interaction