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ROS generation by CL 097 requires ADAM 10 and EGFR activation. (A) Inhibition of CL 097 by GI 254023X (*P < 0.05 v veh, † P < 0.05 v CL 097). (B and C) Attenuation of responses to CL 097 by silencing of ADAM 10 or EGFR (*P < 0.05 v veh, † P < 0.05 v CL 097 with or without control (con) transfection. Inset images in B and C show immunoblots of ADAM 10 or EGFR in cells transfected with target siRNA or control siRNA (con).
