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Intracellular ROS formation by poly i:c or CL 097 requires thrombin formation. (A and B) Inhibition by argatroban (*P < 0.05 v vehicle (veh), † P < 0.05 v poly i:c or CL 097). (C and D) Knockdown of prothrombin (PT) expression by siRNA blocks ROS generation in response to BzATP, poly i:c and CL 097 (*P < 0.05 v veh, † P < 0.05 v agonists in non‐transfected or transfection control (con) cells).
