Figure 9.

(A and B) TAK‐242 inhibits ROS generation by BzATP or UTP. The bar charts show the corresponding negative and positive controls (*P < 0.05 v vehicle (veh)). The effects of TAK‐242 were statistically significant at 10⁻⁷ M and higher. (C and D) Cell silencing of prothrombin (PT) or TLR4 attenuates responses to BzATP or UTP (*P < 0.05 v veh; **P < 0.05 v BzATP or UTP in non‐transfected cells or transfection controls, ^† P < 0.05 v response in non‐transfected cells, ^‡ P < 0.05 v veh). (E and F) Cell silencing of TLR3 or TLR4 inhibits responses to poly i:c or CL 097 (*P < 0.05 v veh, **P < 0.05 v non‐transfected cells or transfection controls, ^† P < 0.05 v CL097 in non‐transfected cells or transfection controls, ^‡ P < 0.05 v veh).