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. 2018 Jan 3;6(2):221–233. doi: 10.1002/iid3.210

Figure 7.

Figure 7

T‐bet is co‐expressed with Egr2 in tolerant T cells. (A) Naïve CD4 T cells (CD62L+CD44lo) from wild‐type (WT) and CD2‐Egr2/3−/− (Egr2/3−/−) mice were stimulated with anti‐CD3 alone for 24 h, then washed and rested for 24 h before re‐stimulation with anti‐CD3 and anti‐CD28 (Tol). After 24 h expression of T‐bet and Egr2 was analyzed and compared to naïve and activated T cells (Act). (B) GFP‐Egr2 knockin and CD2‐Egr2/3−/− mice were injected with SEA once to activate T cells (Act) or five times with 4 day intervals to induce tolerance (Tol). Twenty‐four hours after the last injection, CD3+CD4+TCRVβ3+ cells were analyzed for T‐bet and Egr2 expression. Data in A are from pooled cells of three mice and are representative of three experiments. Data in B are from four mice in each group and are representative of two experiments.