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. 2018 Feb 12;6(2):256–263. doi: 10.1002/iid3.214

Figure 3.

Figure 3

Fetal CD45RO+ Treg are highly suppressive. In vitro suppression assays of cord blood lymphocytes (CBL). (A) Proliferation of total CBL stimulated with ConA with no Treg (black bar), CD45RA+ (gray bar 1:10) or CD45RO+ Treg (white bar 1:10) added. Depicted is a representative result from four independent experiments. Ordinary one‐way ANOVA *p = 0.0135. (B) Proliferation of CD4+ Treg depleted (CD25+ CD127lo) CBL stimulated with irradiated total maternal lymphocytes (1:1) with no fetal Treg (black bar), CD45RA+ (gray bar 1:10) or CD45RO+ Treg (white bar 1:10) added. Depicted is a representative result from three independent experiments (ditto). Ordinary one‐way ANOVA ***p = 0.0001.