Table 1.
Demographic and laboratory data in OIT-responders and OIT-nonresponders.
| OIT-Responders (n = 39) | OIT-Nonresponders (n = 12) | p Value | |
|---|---|---|---|
| Age (years) | 66.0 (18.0) | 62.5 (13.8) | 0.46 |
| Female (%) | 52 | 33 | 0.32 |
| Body mass index (kg/m2) | 21.3 (4.0) | 21.9 (3.6) | 0.84 |
| HD vintage (years) | 4.5 (10.5) | 4.0 (7.8) | 0.50 |
| spKt/V | 1.49 (0.4) | 1.35 (0.59) | 0.65 |
| Hb (g/L) | 10.3 (1.4) | 9.2 (1.3) * | 0.04 |
| MCV (fL) | 84.8 (8.1) | 85.9 (8.6) | 0.49 |
| Serum ferritin (pmol/L) | 39.8 (51.2) | 29.2 (53.4) | 0.47 |
| Serum iron (μmol/l) | 12.5 (10.7) | 8.3 (8.2) | 0.13 |
| TSAT (%) | 18.2 (14.5) | 15.5 (13.8) | 0.71 |
| Serum hepcidin (nmol/L) | 5.1 (10.1) | 2.8 (6.7) | 0.25 |
| Serum creatinine (μmol/L) | 1034 (309) | 919 (265) | 0.50 |
| Serum albumin (g/L) | 35 (5) | 36 (2) | 0.34 |
| Serum triglycerides (mmol/L) | 0.95 (0.44) | 1.42 (0.96) * | 0.02 |
| Serum calcium (mmol/L) | 2.4 (0.1) | 2.4 (0.4) | 0.35 |
| Serum phosphorus (mmol/L) | 1.7 (0.6) | 1.8 (0.5) | 0.66 |
| i-PTH (ng/L) | 62.0 (82.0) | 50.5 (84.5) | 0.62 |
| CRP (mg/L) | 0.4 (0.9) | 0.6 (0.8) | 0.69 |
| CERA dose (μg/week) | 150 (50) | 150 (62.5) | 0.73 |
| Comorbidities (%) | |||
| Diabetes mellitus | 32 | 33 | |
| Hypertension | 85 | 67 | |
| Coronary artery disease | 26 | 25 | |
| Congestive heart failure | 0 | 0 | |
| Vascular disease | 8 | 8 |
Data are expressed as median (interquartile). OIT, oral iron therapy; CRP, C-reactive protein; HD, hemodialysis; CERA, continuous erythropoietin receptor activator; i-PTH, intact parathyroid hormone; MCV, mean corpuscular volume; TSAT, transferrin saturation. Comparison of two nonparametric data groups were determined by the Mann-Whitney U test. * p < 0.05, vs. OIT responders.