Table 2.
Phenylephrine | Acetylcholine | SNP | |||
---|---|---|---|---|---|
Group | pEC50 (mol/L) | Maximal Contraction (g) | Maximal Relaxation (%) | After Acute L-NAME | Maximal Relaxation (%) |
C | −6.45 ± 0.086 | 2.37 ± 0.15 | 82.70 ± 2.50 | 27.38 ± 6.54 | 99.38 ± 1.62 |
L-N | −6.83 ± 0.064 * | 2.54 ± 0.12 | 19.88 ± 4.14 * | 4.55 ± 2.70 * | 89.71 ± 2.03 * |
A | −6.56 ± 0.09 † | 2.76 ± 0.37 | 35.87 ± 6.89 * | 18.47 ± 3.92 † | 96.14 ± 1.73 |
LE | −6.77 ± 0.12 | 2.16 ± 0.10 | 31.57 ± 8.23 * | 5.74 ± 3.93 * | 91.65 ± 3.12 |
GBO | −7.22 ± 0.18 * | 2.18 ± 0.49 | 21.96 ± 5.32 * | 7.67 ± 1.02 * | 84.74 ± 2.93 *,† |
COE | −7.08 ± 0.14 * | 2.09 ± 0.02 | 29.63 ± 3.99 * | 13.65 ± 2.40 † | 90.50 ± 1.57 * |
D | −7.00 ± 0.14 * | 2.01 ± 0.34 | 13.78 ± 4.77 * | 5.23 ± 1.81 * | 91.59 ± 3.13 |
Data are mean ± S.E.M. Abbreviations as in Table 1. pEC50 is the negative logarithm of the half maximal effective concentration (EC50). * p < 0.05 vs. Control; † p < 0.05 vs. L-NAME.