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Therapeutic drug levels of soluble guanylate cyclase (sGC) modulators, BAY 41-8543 and BAY 54-6544, do not affect systemic blood pressure and heart rate (HR) in wild-type C57/Bl6 mice. Mean arterial pressures (MAPs) and HR in mice treated for 5 days with placebo versus the sGC modulators, BAY 41-8543 (150 ppm, n = 4 [A]), BAY 54-6544 (80 ppm, n = 5 [B]), or the PDE5 inhibitor, sildenafil (1,500 ppm, n = 7 [C]), during active and inactive (rest) states.
