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. 2018 May 10;6:38. doi: 10.1186/s40478-018-0542-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — RGC axon functional deficits are associated with astrocyte connectivity in DBA/2 J optic nerve. a. Higher levels of Cx43 are associated with a greater degree of parallelism of GFAP-labeled astrocyte processes in proximal segments of DBA/2 J nerve (left, R = 0.66; p = 0.04) but not distal (right, R = 0.11; p = 0.77). b Intact anterograde transport to the superior colliculus is well-predicted by levels of Cx43 in the distal optic nerve (right, R = 0.88; p < 0.001), but not proximal (left, R = 0.39; p = 0.23). Scale: 100 μm (a)