Table 3.
Associations with incident all-cause and cardiovascular disease (CVD) mortality for density and volume measures analyzed in the same model in European American and African American participants with type 2 diabetes
Outcome | CAC measure | European Americans | African Americans | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Hazard ratio | 95% confidence interval | p-value | n | Hazard ratio | 95% confidence interval | p-value | n | ||||
All-cause mortality | Volume | 1.60 | 1.29 | 1.99 | 2.25 × 10−5 | 889 | 1.76 | 1.22 | 2.53 | 0.003 | 552 |
Density | 1.10 | 0.94 | 1.28 | 0.225 | 889 | 0.77 | 0.55 | 1.07 | 0.117 | 552 | |
CVD mortality | Volume | 1.78 | 1.30 | 2.44 | 3.70 × 10−4 | 875 | 2.56 | 1.40 | 4.67 | 0.002 | 544 |
Density | 1.13 | 0.92 | 1.39 | 0.252 | 875 | 0.69 | 0.43 | 1.10 | 0.121 | 544 |
Hazard ratios for mortality associations reported per standard deviation change in coronary artery calcification measures. Models adjusted for age, sex, statin use, total cholesterol, HDL, systolic blood pressure, high blood pressure medication use, and current smoking; analyses additionally adjusted for study (Diabetes Heart Study or African American Diabetes Heart Study) in African Americans. All calcification measures were derived using a 90 HU (Hounsfield unit) threshold