Table 1.

Consequences of ‘wrong thing–wrong time’ leading to circadian desynchronisation in critically ill patients

Circadian misalignment	Clinical outcome
Sleep–wake inversion	Sleep loss [113]
	Delirium [114]
	Poor compliance with physiotherapy and rehabilitation [115]
Continuous feeding at night time	Glucose intolerance [64]
	Dyslipidaemia [72]
	Metabolic dysfunction [71]
Invasive interventions at night time	Impaired wound healing [101]